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1

Value Creation in the Pharmaceutical Industry (The Critical Path to Innovation) || A Review of the Pharmaceutical R&D Efficiency: Costs, Timelines, and Probabilities

Schuhmacher, Alexander, Hinder, Markus, Gassmann, Oliver

Year:

2016

Language:

english

File:

PDF, 282 KB

english, 2016

2

The present and future of project management in pharmaceutical R&D

Schuhmacher, Alexander, Gassmann, Oliver, Hinder, Markus, Kuss, Michael

Journal:

Drug Discovery Today

Year:

2020

File:

PDF, 1.20 MB

2020

3

Leading Pharmaceutical Innovation || The Pipeline Challenge: How to Organize Innovation

Gassmann, Oliver, Schuhmacher, Alexander, von Zedtwitz, Max, Reepmeyer, Gerrit

Year:

2018

Language:

english

File:

PDF, 537 KB

english, 2018

4

Radionuclide Production from Lead by Neutron-Induced Reactions up to 175 MeV

Glasser, Wolfgang, Michel, Rolf, Neumann, Sonja, Schuhmacher, Helmut, Dangendorf, Volker, Nolte, Ralf, Herpers, Ulrich, Smirnov, Andrey N., Ryzhov, Igor, Prokofiev, Alexander V., Malmborg, Petter, Kol

Journal:

Journal of Nuclear Science and Technology

Year:

2002

Language:

english

File:

PDF, 462 KB

english, 2002

5

The impact of crowdsourcing in modern drug discovery

Schuhmacher, Alexander, Kuss, Michael

Journal:

Expert Opinion on Drug Discovery

Year:

2020

File:

PDF, 571 KB

2020

6

Leading Pharmaceutical Innovation ||

Gassmann, Oliver, Schuhmacher, Alexander, von Zedtwitz, Max, Reepmeyer, Gerrit

Year:

2018

Language:

english

File:

PDF, 4.05 MB

english, 2018

7

Secondary gastrectomy for stage IV gastroesophageal adenocarcinoma after induction-chemotherapy

Novotny, Alexander R., Reim, Daniel, Friess, Helmut M., Schuhmacher, Christoph

Journal:

Langenbeck's Archives of Surgery

Year:

2014

Language:

english

File:

PDF, 417 KB

english, 2014

8

Leading Pharmaceutical Innovation || Innovation: Key to Success in the Pharmaceutical Industry

Gassmann, Oliver, Schuhmacher, Alexander, von Zedtwitz, Max, Reepmeyer, Gerrit

Year:

2018

Language:

english

File:

PDF, 626 KB

english, 2018

9

Leading Pharmaceutical Innovation || The Make-or-Buy Challenge: How to In- and Outsource Innovation

Gassmann, Oliver, Schuhmacher, Alexander, von Zedtwitz, Max, Reepmeyer, Gerrit

Year:

2018

Language:

english

File:

PDF, 788 KB

english, 2018

10

The Legionella pneumophila Methyltransferase RomA Methylates Also Non-histone Proteins during Infection

Schuhmacher, Maren Kirstin, Rolando, Monica, Bröhm, Alexander, Weirich, Sara, Kudithipudi, Srikanth, Buchrieser, Carmen, Jeltsch, Albert

Journal:

Journal of Molecular Biology

Year:

2018

Language:

english

File:

PDF, 784 KB

english, 2018

11

Soil and indoor dust as environmental media of human exposure to As, Cd, Cu, and Pb near a copper smelter in central Chile

Berasaluce, Maite, Mondaca, Pedro, Schuhmacher, Marta, Bravo, Manuel, Sauvé, Sébastien, Navarro-Villarroel, Claudia, Dovletyarova, Elvira A., Neaman, Alexander

Journal:

Journal of Trace Elements in Medicine and Biology

Year:

2019

Language:

english

File:

PDF, 787 KB

english, 2019

12

Leading Pharmaceutical Innovation || The Industry Challenge: Who Would Want to Be in This Business?

Gassmann, Oliver, Schuhmacher, Alexander, von Zedtwitz, Max, Reepmeyer, Gerrit

Year:

2018

Language:

english

File:

PDF, 590 KB

english, 2018

13

Models for open innovation in the pharmaceutical industry

Schuhmacher, Alexander, Germann, Paul-Georg, Trill, Henning, Gassmann, Oliver

Journal:

Drug Discovery Today

Year:

2013

Language:

english

File:

PDF, 291 KB

english, 2013

14

Value Creation in the Pharmaceutical Industry (The Critical Path to Innovation) || The Role of Modern Portfolio Management in Pharma Innovation

Schuhmacher, Alexander, Hinder, Markus, Gassmann, Oliver

Year:

2016

Language:

english

File:

PDF, 274 KB

english, 2016

15

Value Creation in the Pharmaceutical Industry (The Critical Path to Innovation) || The Value of Pharmaceutical Innovation: Concepts and Assessment

Schuhmacher, Alexander, Hinder, Markus, Gassmann, Oliver

Year:

2016

Language:

english

File:

PDF, 208 KB

english, 2016

16

Mesothelin-targeted thorium-227 conjugate (MSLN-TTC): Preclinical evaluation of a new targeted alpha therapy for mesothelin-positive cancers

Hagemann, Urs B, Ellingsen, Christine, Schuhmacher, Joachim, Kristian, Alexander, Mobergslien, Anne, Cruciani, Véronique, Wickstroem, Katrine, Schatz, Christoph A., Kneip, Christoph, Golfier, Sven, Sm

Journal:

Clinical Cancer Research

Year:

2019

Language:

english

File:

PDF, 3.18 MB

english, 2019

17

Author Correction: Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate

Schuhmacher, Maren Kirstin, Beldar, Serap, Khella, Mina S., BrÃ¶hm, Alexander, Ludwig, Jan, Tempel, Wolfram, Weirich, Sara, Min, Jinrong, Jeltsch, Albert

Journal:

Communications Biology

Year:

2020

File:

PDF, 298 KB

2020

18

MALDI Imaging Identifies Prognostic Seven-Protein Signature of Novel Tissue Markers in Intestinal-Type Gastric Cancer

Benjamin Balluff, Sandra Rauser, Stephan Meding, Mareike Elsner, Cedrik Schöne, Annette Feuchtinger, Christoph Schuhmacher, Alexander Novotny, Uta Jütting, Giuseppina Maccarrone, Hakan Sarioglu, Mariu

Journal:

The American Journal of Pathology

Year:

2011

Language:

english

File:

PDF, 2.17 MB

english, 2011

19

How to create innovation by building the translation bridge from basic research into medicinal drugs: an industrial perspective

Paul G Germann, Alexander Schuhmacher, Juan Harrison, Ronald Law…

Journal:

Year:

2013

Language:

english

File:

PDF, 671 KB

english, 2013

20

Value Creation in the Pharmaceutical Industry (The Critical Path to Innovation) || Financing Pharmaceutical Innovation

Schuhmacher, Alexander, Hinder, Markus, Gassmann, Oliver

Year:

2016

Language:

english

File:

PDF, 476 KB

english, 2016

21

Impaired PARP activity in response to the β-adrenergic receptor agonist isoproterenol

Thomas, Mara, Palombo, Philipp, Schuhmacher, Tamara, von Scheven, Gudrun, Bazylianska, Viktoriia, Salzwedel, Judy, Schäfer, Nadine, Bürkle, Alexander, Moreno-Villanueva, María

Journal:

Toxicology in Vitro

Year:

2018

Language:

english

File:

PDF, 1.61 MB

english, 2018

22

Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate its Catalytic Activity

Bröhm, Alexander, Elsawy, Hany, Rathert, Philipp, Kudithipudi, Srikanth, Schoch, Tabea, Schuhmacher, Maren Kirstin, Weirich, Sara, Jeltsch, Albert

Journal:

Journal of Molecular Biology

Year:

2019

File:

PDF, 10.59 MB

2019

23

Value Creation in the Pharmaceutical Industry (The Critical Path to Innovation) || Challenges and Options for Drug Discovery

Schuhmacher, Alexander, Hinder, Markus, Gassmann, Oliver

Year:

2016

Language:

english

File:

PDF, 307 KB

english, 2016

24

Molecular mechanisms of the crosstalk between mitochondrial and NADPH oxidase derived reactive oxygen species in white blood cells — Implications for cardiovascular diseases

Philip Wenzel, Swenja Schuhmacher, Matthias Oelze, Alexander Scholz, Steffen Daub, Maike Knorr, Ning Xia, Christian Otto, Benjamin Opitz, Eberhard Schulz, Huige Li, Karl J. Lackner, Thomas Münzel, And

Journal:

Vascular Pharmacology

Year:

2012

Language:

english

File:

PDF, 53 KB

english, 2012

25

Value Creation in the Pharmaceutical Industry (The Critical Path to Innovation) || Translational Medicine: Enabling the Proof of Concepts

Schuhmacher, Alexander, Hinder, Markus, Gassmann, Oliver

Year:

2016

Language:

english

File:

PDF, 283 KB

english, 2016

26

Value Creation in the Pharmaceutical Industry (The Critical Path to Innovation) || Preclinical Safety and Risk Assessment

Schuhmacher, Alexander, Hinder, Markus, Gassmann, Oliver

Year:

2016

Language:

english

File:

PDF, 594 KB

english, 2016

27

Value Creation in the Pharmaceutical Industry (The Critical Path to Innovation) || Developing Commercial Solutions for Therapeutic Proteins

Schuhmacher, Alexander, Hinder, Markus, Gassmann, Oliver

Year:

2016

Language:

english

File:

PDF, 363 KB

english, 2016

28

High-energy neutron detection and spectrometry with superheated emulsions

Francesco d’Errico, Alexander Prokofiev, Alexander Sannikov, Helmut Schuhmacher

Journal:

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

Year:

2003

Language:

english

File:

PDF, 125 KB

english, 2003

29

Cell cycle activation by c-myc in a Burkitt lymphoma model cell line

Alexander Pajic, Dimitry Spitkovsky, Barbara Christoph, Bettina Kempkes, Marino Schuhmacher, Martin S. Staege, Markus Brielmeier, Joachim Ellwart, Franz Kohlhuber, Georg W. Bornkamm, Axel Polack, Dirk

Journal:

International Journal of Cancer

Year:

2000

Language:

english

File:

PDF, 126 KB

english, 2000

30

Quantitative low energy depth profiling of SiGe laterally nonuniform structures

Merkulov, Alexander, Peres, Paula, Larson, David James, Schuhmacher, Michel

Journal:

Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures

Year:

2018

Language:

english

File:

PDF, 563 KB

english, 2018

31

Leading Pharmaceutical Innovation || The Science and Technology Challenge: How to Find New Drugs

Gassmann, Oliver, Schuhmacher, Alexander, von Zedtwitz, Max, Reepmeyer, Gerrit

Year:

2018

Language:

english

File:

PDF, 373 KB

english, 2018

32

Nitroglycerin-induced endothelial dysfunction and tolerance involve adverse phosphorylation and S-glutathionylation of endothelial nitric oxide synthase — Beneficial effects of therapy with the AT1-receptor blocker telmisartan

Maike Knorr, Sebastian Steven, Michael Hausding, Swenja Kröller-Schuhmacher, Matthias Oelze, Tjebo Heeren, Alexander Scholz, Tommaso Gori, Philip Wenzel, Eberhard Schulz, Andreas Daiber, Thomas Münzel

Journal:

Vascular Pharmacology

Year:

2012

Language:

english

File:

PDF, 87 KB

english, 2012

33

Changing R&D models in research-based pharmaceutical companies

Schuhmacher, Alexander, Gassmann, Oliver, Hinder, Markus

Journal:

Journal of Translational Medicine

Year:

2016

Language:

english

File:

PDF, 1.08 MB

english, 2016

34

Leading Pharmaceutical Innovation || The Open Innovation Challenge: How to Partner for Innovation

Gassmann, Oliver, Schuhmacher, Alexander, von Zedtwitz, Max, Reepmeyer, Gerrit

Year:

2018

Language:

english

File:

PDF, 469 KB

english, 2018

35

Antagonistic effects of c-myc and Epstein-Barr virus latent genes on the phenotype of human B cells

Alexander Pajic, Martin S. Staege, Diana Dudziak, Marino Schuhmacher, Dimitri Spitkovsky, Günther Eissner, Markus Brielmeier, Axel Polack, Georg W. Bornkamm

Journal:

International Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 320 KB

english, 2001

36

Comparison of direct and indirect antioxidant effects of linagliptin with other gliptins — Evidence for antioxidant and antiinflammatory properties of linagliptin

Swenja Kröller-Schuhmacher, Maike Knorr, Matthias Oelze, Alexandra Schuff, Michael Hausding, Richard Schell, Stephan Sudowe, Alexander Scholz, Steffen Daub, Susanne Karbach, Sabine Kossmann, Eberhard

Journal:

Vascular Pharmacology

Year:

2012

Language:

english

File:

PDF, 69 KB

english, 2012

37

Membrane topology of CadA homologous P-type ATPase of Helicobacter pylori as determined by expression of phoA fusions in Escherichia coli and the positive inside rule

Klaus Melchers, Alexander Schuhmacher, Anita Buhmann, Thomas Weitzenegger, Dominique Belin, Sandra Grau, Michael Ehrmann

Journal:

Research in Microbiology

Year:

1999

Language:

english

File:

PDF, 673 KB

english, 1999

38

Value Creation in the Pharmaceutical Industry (The Critical Path to Innovation) || Introduction to the Book

Schuhmacher, Alexander, Hinder, Markus, Gassmann, Oliver

Year:

2016

Language:

english

File:

PDF, 300 KB

english, 2016

39

Leading Pharmaceutical Innovation || The Internationalization Challenge: Where to Access Innovation

Gassmann, Oliver, Schuhmacher, Alexander, von Zedtwitz, Max, Reepmeyer, Gerrit

Year:

2018

Language:

english

File:

PDF, 343 KB

english, 2018

40

Value Creation in the Pharmaceutical Industry (The Critical Path to Innovation) || The Evolution of Clinical Development: From Technical Success to Clinical Value Creation

Schuhmacher, Alexander, Hinder, Markus, Gassmann, Oliver

Year:

2016

Language:

english

File:

PDF, 289 KB

english, 2016

41

SPIE Proceedings [SPIE BiOS '98 International Biomedical Optics Symposium - San Jose, CA (Tuesday 27 January 1998)] Advances in Optical Biophysics - Quantification of the interaction of neuronal adhesion molecules by flow cytometry using microbeads

Tarnok, Attila, Noehrenberg, Ursel, Schuhmacher, Stephan, Volkmer, Hans-Juergen, Lakowicz, Joseph R., Ross, J. B. Alexander

Year:

1998

Language:

english

File:

PDF, 1.41 MB

english, 1998

42

Predicting Individual Survival After Gastric Cancer Resection

Novotny, Alexander R., Schuhmacher, Christoph, Busch, Raymonde, Kattan, Michael W., Brennan, Murray F., Siewert, J??rg R??diger

Journal:

Annals of Surgery

Year:

2006

Language:

english

File:

PDF, 458 KB

english, 2006

43

Value Creation in the Pharmaceutical Industry (The Critical Path to Innovation) || Translational Development

Schuhmacher, Alexander, Hinder, Markus, Gassmann, Oliver

Year:

2016

Language:

english

File:

PDF, 362 KB

english, 2016

44

Control of cell growth by c-Myc in the absence of cell division

Marino Schuhmacher, Martin S. Staege, Alexander Pajic, Axel Polack, Ulrich H. Weidle, Georg W. Bornkamm, Dirk Eick, Franz Kohlhuber

Journal:

Current Biology

Year:

1999

Language:

english

File:

PDF, 93 KB

english, 1999

45

Value Creation in the Pharmaceutical Industry (The Critical Path to Innovation) || Forty Years of Innovation in Biopharmaceuticals - Will the Next 40 Years Be as Revolutionary?

Schuhmacher, Alexander, Hinder, Markus, Gassmann, Oliver

Year:

2016

Language:

english

File:

PDF, 700 KB

english, 2016

46

Neoadjuvant Treatment for Gastric Cancer

Schuhmacher, Christoph, Reim, Daniel, Novotny, Alexander

Journal:

Journal of Gastric Cancer

Year:

2013

Language:

english

File:

PDF, 1.26 MB

english, 2013

47

Value Creation in the Pharmaceutical Industry (The Critical Path to Innovation) || Vaccines: Where Inertia, Innovation, and Revolution Create Value, Simultaneously and Quietly

Schuhmacher, Alexander, Hinder, Markus, Gassmann, Oliver

Year:

2016

Language:

english

File:

PDF, 517 KB

english, 2016

48

Open innovation and external sources of innovation. An opportunity to fuel the R&D pipeline and enhance decision making?

Schuhmacher, Alexander, Gassmann, Oliver, McCracken, Nigel, Hinder, Markus

Journal:

Journal of Translational Medicine

Year:

2018

Language:

english

File:

PDF, 1.22 MB

english, 2018

49

The upside of being a digital pharma player

Schuhmacher, Alexander, Gatto, Alexander, Hinder, Markus, Kuss, Michael, Gassmann, Oliver

Journal:

Drug Discovery Today

Year:

2020

File:

PDF, 815 KB

2020

50

Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate

Schuhmacher, Maren Kirstin, Beldar, Serap, Khella, Mina S., BrÃ¶hm, Alexander, Ludwig, Jan, Tempel, Wolfram, Weirich, Sara, Min, Jinrong, Jeltsch, Albert

Journal:

Communications Biology

Year:

2020

File:

PDF, 2.42 MB

2020

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